Purpose: The aim of our study was to evaluate retinal function with white light dark‐adapted full‐field sensitivity threshold (FST) and find possible correlations with metabolic function measured with retinal oximetry (RO) in patients with retinitis pigmentosa (RP). Methods: In this prospective observational study (BASEC 2020–00122), FST and RO measurements were performed on 66 RP eyes (33 subjects, 12♀ 21♂) aged between 18 and 80 years (mean 43.2 years); all eyes were graded for disease severity. Main outcome parameters were white FST thresholds using the Diagnosys Espion system with the ColorDomeTM LED full‐field stimulator (Diagnosys LLC, Lowell, MA) as well as the main RO parameters: the mean arterial (A‐SO2; %), venular (V‐SO2; %) oxygen saturation, their difference (A‐V SO2; %), and the corresponding mean diameters of the peripapillary retinal arterioles (D‐A; μm) and venules (D‐V; μm) recorded with the oxygen saturation tool of the Retinal Vessel Analyser (RVA; IMEDOS Systems UG, Jena, Germany). In addition, semi‐automated kinetic perimetry (V4e, III4e, I4e, III3e isopters, Octopus 900®, Haag‐Streit AG Bern, Switzerland) was performed and included in the linear mixed‐effects models analysis calculated with SPSS®. Results: Neither the oxygen saturation parameters (p > 0.21) nor the D‐A and D‐V (p > 0.13) showed significant correlations with the FST. However, when compared systematically with the visual field (VF) areas of the different isopters, RO parameters V‐SO2 (p = 0.024) and A‐V SO2 (p < 0.02) showed significant correlations. Furthermore, both V‐SO2 and A‐V SO2 showed gradual changes with more pronounced impairment in oxygen metabolic function in advanced stages of RP when analysed in subgroups of disease severity grades. Conclusions: In advanced stages of RP, RO showed a significant association with standardized VF testing parameters and presented with gradual changes of more pronounced impairment in retinal oxygen metabolic function. Unlike standardized VF parameters, white dark‐adapted FST does not appear to correlate with retinal oxygen metabolic function in RP patients, implying that the two examinations may capture unrelated aspects of the retinal pathological process.

To evaluate clinical outcome after surgery of idiopathic epiretinal membranes (ERM) with internal limiting membrane (ILM) peeling using a commercial combination of Brilliant blue G (BBG, 0.25 mg/ml) with 4% polyethylene glycol (PEG). Methods It was a prospective, single-center study. Macular surgery was performed due to ERM (n = 18) by two experienced surgeons. Exclusion criteria were secondary ERM, previous retinal surgery and pharmacological treatment. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and multifocal ERG (RETIscan) were assessed at baseline and three months after surgery. Results The BCVA improved from baseline 0.4 ± 0.13 logMAR to 0.3 ± 0.2 logMAR after three months (p > 0.05). The mean central foveal thickness was reduced from 407 ± 85 μm to 366 ± 56 μm after three months (p > 0.05). At baseline, the mean P1 amplitude (nV/deg 2) was 53.5 ± 32.1 in ring 1 and 35.9 ± 20.1 in ring 2. Three months after surgery the mean P1 amplitude was comparable with 57.2 ± 16.3 in ring 1 and 38.0 ± 11.7 in ring 2 compared with the initial situation (p = 0.22 and p = 0.3, respectively). Conclusion BBG with 4% PEG can be used for ILM peeling in patients with idiopathic epiretinal membranes without any sign of short-term toxicity.

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