sto the target SVG. Extent score, diabetes and patient's age at the time of the procedure were independently associated with risk of death on follow-up.Conclusions: Periprocedural troponin rise, diabetes and high SVG extent score are predictive of poorer long-term outcome following PCI. The effect of high extent score and diabetes persists past 6 years.

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThe recent dramatic decline in settlement in the population of the spiny lobster, Panulirus cygnus, may be due to changes in the oceanographic processes that operate offshore of Western Australia. It has been suggested that this decline could be related to poor nutritional condition of the post-larvae, especially lipid which is accumulated in large quantities during the preceding extensive pelagic larval stage. The current study focused on investigations into the lipid content and fatty acid (FA) profiles of lobster phyllosoma larvae from three mid to late stages of larval development (stages VI, VII, VIII) sampled from two cyclonic and two anticyclonic eddies of the Leeuwin Current off Western Australia. The results showed significant accumulation of lipid and energy storage FAs with larval development regardless of location of capture, however, larvae from cyclonic eddies had more lipid and FAs associated with energy storage than larvae from anticyclonic eddies. FA food chain markers from the larvae indicated significant differences in the food webs operating in the two types of eddy, with a higher level of FA markers for production from flagellates and a lower level from copepod grazing in cyclonic versus anticyclonic eddies. The results indicate that the microbial food web operating in cyclonic eddies provides better feeding conditions for lobster larvae despite anticyclonic eddies being generally more productive and containing greater abundances of zooplankton as potential prey for lobster larvae. Gelatinous zooplankton, such as siphonophores, may play an important role in cyclonic eddies by accumulating dispersed microbial nutrients and making them available as larger prey for phyllosoma. The markedly superior nutritional condition of lobster larvae feeding in the microbial food web found in cyclonic eddies, could greatly influence their subsequent settlement and recruitment to the coastal fishery.

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Background: Management of atrial fibrillation is frequently challenging, and traditionally catheter or surgical procedures are the main modalities for ablation. Minimally invasive thoracoscopic techniques recently developed endeavor to preserve the advantages of both traditional modalities. We reviewed the efficacy and safety of minimally-invasive MAZE to treat atrial fibrillation in this meta-analysis. Methods: We searched Pubmed and Embase databases from 1 January 1980 to 30 June 2015 for original studies. Two authors evaluated these studies for inclusion independently, and retrieved data for pooled analyses. Results: From the search, 1,098 abstracts were screened with 206 full-articles evaluated for the final inclusion of 31 studies (all observational). Pooled proportion of patients in sinus rhythm at 3 months was 0.85 (0.77-0.93) in 5 studies, at 6 months was 0.88 (0.83-0.94) in 8 studies and at 12 months was 0.84 (0.81-0.97) in 6 studies. Pooled proportion of patients off anti-arrhythmic drugs at 3 months was 0.52 (0.01-1.03) in 3 studies, at 6 months as 0.73 (0.64-0.83) in 9 studies and at 12 months 0.67 (0.58-0.77) in 11 studies. Adverse event rates of mortality (0-2%), stroke/TIA (0-3%) and bleeding (0-15%) in studies reported were low. Conclusion: Efficacy and safety of minimally-invasive MAZE is high and similar to catheter and surgical ablation. Ongoing development and larger and randomised studies of this procedure would facilitate more precise comparisons with other treatment modalities and guide clinical practice.