Phytochemical studies of the roots and aerial parts of endemic Arnebia purpurea S. Erik & H. Sumbul resulted in the isolation and characterization of four naphthoquinones [isovalerylalkannin (1), α-methyl-n-butanoyl alkannin (2), acetylalkannin (3), and alkannin (4)], a triterpene derivative [3-O-acetyl-oleanolic acid (5)], a steroid [β-sitosterol (6)], three flavonoid glycosides [isorhamnetin-3-O-rutinoside (7), kaempferol-3-O-rutinoside (8), kaempferol 3-O-(5''-acetyl) apiofuranoside 7-O-rhamnopyranoside (9)] and a phenolic acid [rosmarinic acid (10)]. 3-O-Acetyl-oleanolic acid, isorhamnetin-3-O-rutinoside, kaempferol-3-O-rutinoside, and kaempferol 3-O-(5''-acetyl) apiofuranoside 7-O-rhamnopyranoside are reported from an Arnebia species for the first time. Cytotoxic activities on L929 murine fibrosarcoma cell line of the isolated compounds were investigated using MTT assay. Naphthoquinones (1-4) showed intermediate cytotoxic activity in comparison with the standard, doxorubicin.

In this research, the flavonoid contents of the ethanol and acetone extracts of the aerial parts of Pimpinella rhodantha, Pimpinella tragium subsp. lithophila, Pimpinella cappadocica and Pimpinella kotschyana (Umbelliferae) were determined as rutin and hyperoside, and the antioxidant activity of the ethanolic extracts of these species was studied by using spectrophotometric assays. As a result, the maximum flavonoids containing plant, Pimpinella cappadocica was shown the highest antioxidant activity among the other researched Pimpinella species.

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