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assistance and protection from the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 2. On preventing and treating health effects from acute, prolonged, and repeated nerve agent exposure, and the identification of medical countermeasures able to reduce or eliminate the longer term health effects of nerve agents, Toxicology (2018),

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A copolymer system with controlled hydrophilicity has been prepared through copolymerization technique and its capability as controlled drug release carrier is investigated. The effect of copolymer composition on water uptake, thermal properties, and morphology is reported. The water uptake increases with increasing N-vinyl pyrrolidone content and diffusion of water molecules appears to be non-Fickian. Dexamethasone has been selected as model drug and its controlled release from selected water stable copolymers follows for more than 1 month. Initial burst release of more than 50% occurs in 7 days. The remaining drug is released in a sustained way upto 37 days. Initial 10 h drug release pattern involves first-order kinetics (NH73) and zero-order kinetics (NH55), whereas initial 60% drug release mechanism appears to be non-Fickian for NH73 (n ¼ 0.71) and Case II transport (n ¼ 1.24) for NH55.