Immunizing human or animals with edible plants is an evolving tool that seems to grip countless potential. The selected/desired antigen of pathogens (HIV, tuberculosis etc) are inserted to the selected host plant by transformation technique to form a transgenic plant. Edible vaccines grip countless promise as a profi table, easily managing, can be store easily, unlikely or unable to fail and sociocultural gladly sustainable, particularly for the poor emerging nations. An edible vaccine takes the place of sore immunization methods. Compare to conventional vaccine, edible vaccine is inexpensive, needle free, eradicates the requirement for preservation, harmless, may be stored nearby to place of usage, and deliver mucosal and complete immunity. For the enhancing immunity in human and animal against Various type of infectious diseases such as cholera, measles, FMD and hepatitis B there are numerous types of edible vaccines are being developed. Edible vaccines also help to overpower auto immunity diseases alike type-I diabetes. Immunization generations and giving malnutrition have the dual advantages of edible vaccine. If the notable problem and challenges may be triumph over It also can bring about a destiny of more secure and further effective immunization.