Background: Young adults with kidney transplants are a group susceptible to depressive symptoms, which can influence their quality of life. The objective was to evaluate the relationship between depression and quality of life in young kidney transplants from a tertiary care unit. Methods: Analytical and cross-sectional study, with convenience sampling. Forty hospitalized adults were included, quality of life was measured with the KDQOL-SF24 questionnaire (Kidney Disease Quality of Life-Short Form 24) and the Hamilton scale was applied to determine the level of depression. Results: The prevalence of depression was 70%; participants with depression showed a lower quality of life in social function (p = 0.039) and mental health (p = 0.016). Conclusions: Young adults with kidney transplantation show a higher prevalence of depression compared to other age groups. It is suggested to identify patients with depression in a timely manner to increase their quality of life after kidney transplantation.