Background: Chronic kidney disease is a chronic inflammatory process which is the main cause of developing atherosclerosis. The main reason of morbidity and mortality in Chronic Kidney Disease (CKD) is atherosclerosis. Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte Ratio (NLR) have been reported as markers of systemic inflammation. Aim of Study: To assess the value of Mean Platelet Volume (MPV) and Neutrophil to Lymphocyte (NLR) in chronic kidney disease patients with proteinurea. Methods: The study was carried out on two groups: Group (I): 50 CKD patients and Group (II): 50 healthy individuals as a control group. The patients were from Outpatient Clinic of Nephrology in Tanta University Hospital. This study was carried out from August 2017 to February 2018. We excluded patients suffer from coronary artery disease, myocardial infarction and heart failure, patients suffer from active infection, patients suffer from diabetes mellitus and patients suffer from malignancy. Complete clinical examination including: Body Mass Index (BMI) and routine laboratory investigations and specific investigations including Neutrophil Lymphocyte Ratio (NLR) and Mean Platelet Volume (MPV) were done. Results: NLR was statistical significance higher in patients group than control healthy groups (Z mw =-7.38, p<.001) and there were statistically significant positive correlation were detected between NLR and proteinuria (p<.001*), CRP (p <.001*), fibrinogen (p<.001 *) and negative correlation with eGFR (p<.001 *). There was not statistical difference of MPV between patients group and control healthy group (t=-.510, p=.611) and there were not statistically significant correlation between MPV and proteinuria (p=.416), CRP (p=.641) and eGFR (p=.557). Conclusion: NLR could be used as a marker of inflammation and proteinuria in CKD stages but MPV needs more researches in this field.