The influence of courtyard on the thermal performance of Development Department office building in University Malaysia Perlis (UniMAP, Pauh Putra campus) is investigated through simulation study for the effect of ventilation on indoor air temperature and relative humidity of the building. The study is carried out using EnergyPlus simulator interface within OpenStudio and SketchUp plug in software to measure both of air temperature and relative humidity hourly on 21 April 2017 as a design day. The results show that the ventilation through the windows facing the courtyard has sufficient effect on reducing the air temperature compared to the ventilation through external windows since natural ventilation is highly effective on driving the indoor warm air out to courtyard. In addition, the relative humidity is reduced due to ventilation since the courtyard has high ability to remove or dilute indoor airborne pollutants coming from indoor sources. This indicates that the presence of courtyard is highly influential on thermal performance of the building.