One of the deadliest infectious diseases in the world is Tuberculosis. The disease is caused by Mycobacterium tuberculosis and causes health problems around the world. Tuberculosis has spread globally. This study used various sources of information from Indonesia Government Agencies. Tuberculosis data was obtained from South Konawe Public Health Office in the period from 2018 to 2020. The data is an annual report published by the South Konawe Public Health Office. Cases tend to increase in men other than women. Men are mostly susceptible to pulmonary TB risk factors. The cure rates percentage for TB patients in South Konawe Regency varies every year, such as in the year 2020 it became very low. The high number of TB patients is in Ranomeeto and Benua sub-districts. Cases show that prevention improvement is needed in these sub-districts. The number of TB patients and mortality rate in South Konawe Regency tend to increase every year. Real actions are needed from the government, health workers and the community itself to reduce the number of sufferers and mortality. Keywords: TB, South Konawe Regency, Indonesia