Hypotension is a common adverse effect seen after spinal anesthesia. In recent literature the use of 5-HT3 receptor antagonists has been proposed to prevent spinal anesthesia induced hypotension (SAIH). We present the use of granisetron in several cases as prevention strategy for SAIH in our center. All 10 eligible subjects received 3 mg granisetron diluted in 10 cc normal saline 5 minutes prior to spinal anesthesia, on patients who undergone non-obstetric procedure. Eight patients showed good response without evidence of hypotension, while the other two patients had hypotension managed well with ephedrine. As many as 9 patients had no bradycardia, while shivering was noted in 3 patients. All patients didn’t suffer from nausea/vomiting, due to its effectiveness of granisetron acts as antiemetic agents. Granisetron, has great affinity specifically for 5-HT3 receptor. It blocked the Bezold Jarisch Reflex (BJR) activation that will lead to hypotension and bradycardia. In a nutshell, granisetron has shown its potential as a prevention strategy for hypotension after spinal anesthesia in the majority of our cases above. Keywords: Hypotension, Spinal anesthesia, granisetron, 5-HT3, BJR.