Understanding mechanisms of human disease can be very challenging for students with a basic background in anatomy and biology, and it can be nearly impossible for students without any prior exposure to these basic sciences. We have designed an approach for understanding human disease for learners of various science backgrounds. By using fictional character associations with disease processes, we have anthropomorphized disease components to make the mechanisms accessible to students with little to no science background, while still appealing and exciting to students with significant science backgrounds. By assisting students in the creation of fictional characters to represent disease processes, we have increased student understanding, engagement, enjoyment, and retention of course content.