There is little research in northern regions on tillage systems in corn (Zea mays L.), soybean [Glycine max(L.) Merr], and wheat (Triticum aestivum L.) rotations. The objectives of this study were to (i) evaluate the influence of tillage on performance of corn, soybean, and winter wheat in rotations with each other, and (ii) determine whether corn or soybean yields could be increased in 3‐yr rotations with wheat compared with an annual rotation with each other. Field studies were conducted near Arlington, WI, for 3 yr (1989 to 1991) on a Piano silt loam soil (fine‐silty, mixed, mesic Typic Argiudoll) under both moldboard plow (MP) and no‐till (NT). Six crop sequences evaluated were: corn/soybean, corn/soybean/wheat, corn/wheat/soybean, and continuous corn, soybean, or wheat. Grain yields for both corn and soybean were similar regardless of crop sequence when these crops were in rotation, with no advantage for 3‐yr vs. 2‐yr sequences. Average yields were reduced 10% (corn) and 15% (soybean) for continuous cropping compared with rotations, with greater yield reductions under NT than MP. Tillage did not influence grain yield for soybean or corn in rotation, but yields were reduced under NT for both crops with monocropping. Grain yields for NT continuous corn were 8% lower than MP, and continuous soybean yields were 7% less with NT than MP. Wheat yields were low and response to tillage and rotation was inconsistent. In this study we found no clear advantage for three‐crop corn, soybean, and wheat rotations compared with an annual rotation of corn and soybean. Research Question Grain producers are converting to reduced tillage systems to reduce soil erosion and field‐work time requirements, and to remain eligible for government programs. Little research has been conducted evaluating tillage systems in crop rotations including corn, soybean, and wheat. The two objectives of this study were to (i) evaluate the influence of tillage on performance of corn, soybean, and winter wheat in rotations with each other and (ii) determine whether corn or soybean yields could be increased in 3‐yr rotations with wheat compared with those in an annual corn/soybean rotation. Literature Summary In northern regions, grain yields for both corn and soybean are generally lower under no‐till than moldboard plow systems when growing either crop continuously, but yields are often similar for these tillage systems when the two crops are rotated. There is little published research available regarding winter wheat response to tillage systems in corn/soybean rotations or of corn/soybean response to tillage following winter wheat. Results of several studies indicate that both corn and soybean yields are limited in 2‐yr, corn/soybean sequences compared with those in rotations in which the two crops are grown less frequently than every other year. Study Description This study was conducted for 3 yr on Piano silt loam soil at Arlington, WI. Treatments: Tillage systems (2) Moldboard plow and no‐till Crop rotation sequences (6) Corn/soybean Corn/so...