Background Preterm birth may leave the brain vulnerable to dysfunction. Knowledge of future neurodevelopmental delay in children born with various degrees of prematurity is needed to inform practice and policy. Objective To quantify the long‐term cognitive, motor, behavioural and academic performance of children born with different degrees of prematurity compared with term‐born children. Search strategy PubMed and Embase were searched from January 1980 to December 2016 without language restrictions. Selection criteria Observational studies that reported neurodevelopmental outcomes from 2 years of age in children born preterm compared with a term‐born cohort. Data collection and analysis We pooled individual estimates of standardised mean differences (SMD) and odds ratios (OR) with 95% confidence intervals using a random effects model. Main results We included 74 studies (64 061 children). Preterm children had lower cognitive scores for FSIQ (SMD: −0.70; 95% CI: −0.73 to −0.66), PIQ (SMD: −0.67; 95% CI: −0.73 to −0.60) and VIQ (SMD: −0.53; 95% CI: −0.60 to −0.47). Lower scores for preterm children in motor skills, behaviour, reading, mathematics and spelling were observed at primary school age, and this persisted to secondary school age, except for mathematics. Gestational age at birth accounted for 38–48% of the observed IQ variance. ADHD was diagnosed twice as often in preterm children (OR: 1.6; 95% CI: 1.3–1.8), with a differential effect observed according to the severity of prematurity (I2 = 49.4%, P = 0.03). Conclusions Prematurity of any degree affects the cognitive performance of children born preterm. The poor neurodevelopment persists at various ages of follow up. Parents, educators, healthcare professionals and policy makers need to take into account the additional academic, emotional and behavioural needs of these children. Tweetable abstract Adverse effect of preterm birth on a child's neurodevelopment persists up to adulthood.

Objectives To determine the accuracy with which uterine artery Doppler in the first trimester of pregnancy predicts pre-eclampsia and fetal growth restriction, particularly early-onset disease. MethodsWe searched MEDLINE (1951MEDLINE ( -2012, EMBASE (1980EMBASE ( -2012 (FVW) in the prediction of early-onset pre-eclampsia were , and in the prediction of early-onset fetal growth restriction were 39.2%

Myasthenia gravis (MG) is a chronic autoimmune disorder of neuromuscular transmission characterized by varying degrees of weakness and easy fatigability of the skeletal muscles. Precipitants of myasthenic symptoms or crises include physical and emotional stress, systemic illness, infections, hypo or hyperthyroidism, pregnancy, any type of surgery with general anaesthesia as well as corticosteroids. The authors report two cases of MG in pregnancy and discuss briefly the various aspects of the disease course and management in pregnancy. As MG occurs predominantly in women of reproductive years, it is important that obstetricians are aware of this condition and its management in pregnancy.

Adenomatoid tumours should always be included in the differential diagnosis along with adenomyosis and post-GnRH analogue treatment changes, when difficulty is encountered in identification of operative planes during a routine laparoscopic myomectomy. Apart from explaining the operative difficulties, the identification of these tumours also helps in post-operative counselling of these patients as these tumours unlike fibroids do not recur.