Background: The importance of the right ventricle as a determinant of exercise capacity and its significant prognostic value in the evaluation of surgical outcomes has been largely proven. In this study, we sought to explore the effect of off-pump coronary artery bypass surgery (OPCAB) on right ventricular (RV) function by the different methods of RV functional assessment on transthoracic echocardiography. Materials and Methods: This is a prospective cohort study. All patients undergoing elective OPCAB were included in the study from July 1, 2016, to October 1, 2016 after an informed consent. Their preoperative, postoperative day 4, and postoperative 2-month transthoracic echocardiographic RV and left ventricular functions were evaluated and analyzed. Results: A total of 48 patients undergoing OPCAB were included in this study. The mean age of the cohort was 57.2 ± 8 years. About 85.4% (41) were males. Overall, there is a significant time effect observed in RV ejection fraction (RVEF), with a significant decline from preoperative to postoperative value and a significant increase from postoperative day 4 to postoperative 2-month value. Although RVEF was lower throughout the study in patients with events than those without events, this difference was not statistically significant. Conclusion: In this Indian cohort of patients undergoing OPCAB, there is a significant drop in RVEF, RV tissue Doppler, tricuspid annular peak systolic excursion on postoperative day 4, and also a significant increase in these values over the next 2 months though not reaching the basal value. Hence, suggesting that the drop in RV function is temporary and recovers over time in patients undergoing OPCAB. Patients with events had a lower RVEF when compared to those without events suggesting prognostication.