Although laparoscopic sleeve gastrectomy (LSG) is a simple procedure, it isn’t standardized when it comes to operative technique. Staple line reinforcement (SLR) is proven to be effective in reducing adverse postoperative outcomes, most importantly leaks and bleeding. However, no enough evidence in the literature supports one SLR method over others. The most prominent SLR methods available are oversewing/suturing (OS/S), omentopexy/gastropexy (OP/GP), Seamguard buttressing (SGB), bovine pericardial strips / peri-strip dry (BPS/PSD) buttressing, and fibrin gluing (FG). This study focuses on comparing BPS/PSD buttressing with no-SLR, OS/S, and Seamguard buttressing (SGB), by compiling all the data published in comparative studies, in a single meta-analysis paper.