Objective To evaluate trends in DOR assignment in the SART CORS database and to evaluate its accuracy in predicting poor ovarian response (POR) as defined in ESHRE’s ‘Bologna Criteria’ (2011). Design Retrospective cohort study. Setting Not applicable. Patients 181,536 fresh, autologous ART cycles reported to SART by US clinics in 2004 and 2011 (earliest and most recent available reporting years). Intervention(s) None. Main Outcome Measure(s) DOR assignment was the primary exposure. POR, defined as cycle cancellation for poor response or <4 oocytes retrieved following conventional gonadotropin stimulation (>149 IU FSH daily), was the primary outcome. Secondary outcomes were live birth and number of oocytes retrieved. DOR prevalence, power of DOR and FSH (

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Objective To compare the pregnancy outcomes in the setting of a single versus double donor sperm intrauterine insemination (IUI) treatment cycle. Design Retrospective cohort study. Setting Large private assisted reproductive technology practice. Patients Donor sperm IUI recipients. Interventions None. Main outcome measures Clinical pregnancy. Results There were 2,486 double and 673 single donor sperm IUI cycles. The two groups were similar for age, body mass index, and the number of prior cycles. The clinical pregnancy rates were similar between the two groups (single: 16.4% versus double: 13.6%). In univariate regression analysis, age, total motile sperm (TMS), and diminished ovarian reserve (DOR) were associated with pregnancy Generalized estimating equation models accounting for repeated measures and age, DOR and TMS and the interactions of these factors demonstrated that single and double IUI had similar odds of pregnancy (OR 1.12, 95%CI 0.96–1.44). Pregnancy rates remained similar between the two groups in matched comparison and other subgroup analyses. Conclusion Single and double donor IUI cycles had similar clinical pregnancy rates. This large data set did not demonstrate a benefit to routine double IUI in donor sperm cycles.