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New studies show a possible benefit of combining Gemcitabine, Oxaliplatin and Cetuximab for the treatment of intrahepatic tumors. However, there is currently no consensus in the literature. Hence, this article contributes to the debate by presenting a case of cholangiocarcinoma (biliary tract cancer), treated with a modified Gemcitabine, Oxaliplatin and Cetuximab protocol, which evolved to a considerable regression of the tumor and a complete radiologic response assessed by PET-CT Scan. The case report is of a female adult, who presented with a cholangiocarcinoma extending to hepatic segments V and VIII which met unresectable criteria. She was submitted to chemotherapy, consisting of a combination of Gemcitabine, Oxaliplatin and Cetuximab for a prolonged period, followed by a maintenance interval of Cetuximab monotherapy. After the 8th cycle, the patient presented better hepatic biomarker levels; after 15 months of treatment, our team achieved optimal partial radiologic response assesed by PET-CT scan as shown; after 15 months of treatment, a MRI scan showed a reduced and resectable tumor. Our case report suggests use of the Gemcitabine + Oxaliplatin (GEMOX) plus Cetuximab protocol as a neoadjuvant setting for patients with unresectable cholangiocarcinoma. Additionally, our case report confirms the GEMOX plus Cetuximab protocol can be modified according to clinical response so patients can obtain maximum therapeutic gain despite minor or adverse reactions.

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

This article is about a partnership of researchers with the Academic League of Oncology of Pará-LAOPA, its objective is to provide a brief exploration, on scientific articles and publications between the years 2010 and 2017, of the general aspects of cancer from a contemporary perspective. The justification lies in the need to deal with cancer-related issues, in this case breast cancer, seeking recognition about possible novelties on the subject, since even with all the subsidies for effective treatment, it still remains a disease with increasing annually. In the conclusion, it is observed that revisiting this theme becomes fundamental not only for academics and professionals, but also for the community in general, in order to serve as a tool for awareness, and actions taken.