TLR2–16934A>T polymorphism could be a genetic predictor of AD severity, the coexistence of asthma or atopic conjunctivitis as well as a family history of atopic diseases, especially in subjects having higher TS IgE. TLR2–16934A>T polymorphism affects transcriptional activity, which may at least in part account for the clinical associations observed for the –16934A>T polymorphism.

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Myocardial infarction and ischemic stroke are associated with formation of dense fibrin clots resistant to lysis. Although pro- and antithrombotic alterations have been reported in atopy, fibrin clot function has not been studied in atopic patients. The aim of the current study was to investigate fibrin clot properties in patients with atopic dermatitis (AD). Plasma fibrin clot permeability, turbidity and clot lysis were assessed in 130 consecutive AD patients, aged 29.7 +/- 11 [+/-SD] years (mean SCORAD index, 32.4 +/- 14.9), free of thrombotic events. A control group comprised 130 healthy controls matched for demographics. Patients with AD had lower clot permeability (7.12 +/- 1.87 vs. 9.32 +/- 0.86 x 10(-9) cm(2); P < 0.0001), increased fiber thickness (maximum clot absorbancy at 405 nm, 4.03 +/- 0.54 vs. 3.47 +/- 0.25), faster clot formation (the lag phase, 39.16 +/- 4.61 vs. 43.05 +/- 4.56 s), higher maximum D-dimer levels released from clots, reflecting increased clot mass (4.05 +/- 0.57 vs. 3.47 +/- 0.25 mg/l; P < 0.0001), lower rate of D-dimer release (0.073 +/- 0.01 vs. 0.078 +/- 0.01 mg/l/min; P < 0.0001), and prolonged fibrinolysis time (9.26 +/- 1.47 vs. 7.81 +/- 1.17 min; P < 0.0001) compared with controls. Concomitant asthma (n = 36; 27.7%) was related to a higher rate of D-dimer release from clots than the remainder (0.075 +/- 0.01 vs. 0.072 +/- 0.01 mg/l/min, respectively; P = 0.03). Altered plasma fibrin clot properties associated with reduced efficiency of fibrinolysis can be detected in AD patients, which might represent a novel mechanism that modulates a hemostatic balance in atopy.

Background. Cellulite affects 85-98% of women aged over 20 years. In a given context, mechanical vibrations have not been applied in the therapy of gynoid lipodystrophy (GL) until now. The aim of this pilot study was to assess the condition and temperature of skin affected by cellulite after vibration therapy interventions in young women with GL. Methods. 10 healthy women (21.5 ± 1.5 years old) with stage 1 or 2 Nürnberger-Müller scale of severity of GL participated in the study. The subjects underwent 20 vibration interventions with the use of a Rehabilitation Massage Device Vitberg+. Vibration therapy was applied 5 times a week for 60 minutes during 4-week period. Before and after first and last interventions, grade of lipodystrophy was assessed and thermographic images were taken. Results. Visual and palpation analysis performed before and after a series of treatments proved a total cellulite remission after the intervention among 40% of subjects (from stage 1 to stage 0). Among the remaining 60% with stage 2 of cellulite, an improvement in the skin condition was observed, and cellulite grade was determined as stage 1. The mean skin temperature in the lateral part of thigh as well as on the posterior surface of thigh and buttocks increased significantly (p<0.00001) after both the first (respectively: 4.0°C ± 0.9°C, 3.9°C ± 0.8°C) and the last vibration therapy interventions (respectively: 3.1°C ± 1.1°C, 2.8°C ± 1.1°C). After the series of interventions, a statistical significant (p=0.00705) increase in the mean skin temperature in the lateral thigh was observed—before the first treatment: 27.9°C ± 0.7°C; before twentieth treatment: 29.0°C ± 1.2°C. Conclusion. The series of vibration interventions contributed to the reduction of GL among the participants. The thermographic imaging analysis proved an impact of both single and serial vibration interventions.

Introduction: Lipodystrophy is a common problem for modern women. So far, no fully effective therapeutic methods have been developed to eliminate this type of change. Vibration massage is a method that has not yet been studied in the prevention and elimination of lipodystrophy symptoms. Aim of the study: The aim of this study was to evaluate the effectiveness of vibrotherapy on the reduction in lipodystrophic changes. Material and method: 10 volunteers with cellulite changes at the age of 21-23 with physical activity levels described by the international IPAQ questionnaire participated in the study. All women included in the study were evaluated on the basis of 5-day nutrition analysis. Before and after 4 weeks of vibrotherapy, waist, hip and thigh circumferences were measured, and body composition was assessed using bioimpedance and dermatoscope photos were taken. Oscillating cycloidal vibration was generated by the Vitberg+ Rehabilitation Device (Nowy Sącz). Results: After the 4-week series of vibrations, the following average reduction in thigh circumference was observed (Δ1.55 cm, p = 0.002 for right thigh, Δ1.50 cm, p = 0.000 for left), hips (Δ1.25 cm, p = 0.006) and waist (Δ2.30 cm, p = 0.002). The proposed treatment series caused a reduction in body fat mass (Δ0.42 kg, p = 0.009) without affecting the body’s water content, and the analysis of dermatoscopic imaging results revealed improvement in skin perfusion. Conclusion: Oscillating-cycloidal vibration therapy can be an effective tool to alleviate lipodystrophic changes