Introduction: Every year hundreds of thousands of people die from injuries caused by firearms. T herefore, the present work aimed to determine and analyze the pattern of firearm injuries among deaths on which medicolegal autopsies were conducted at Cairo Department of Forensic Medicine (Zeinhom mortuary), Ministry of Justice, Egypt, during 2014 .Material and Methods: Data were obtained from available medicolegal reports and were statistically analyzed.Results: There were 468 firearm deaths representing 26.3% of the total deaths received during the study period. Conclusion:Most of cases were males in the age group (20-30) years. In most of the cases (93.4%) there is no relation between assailant and victim. T here was a high prevalence (68.6%) of rifled weapons and chest was the most common injured anatomical region (38.2%), followed by head (36.9%). Homicidal manner was the most common (91.7%) and the majority (88.5%) of cases died suddenly without any medical intervention. T he major mechanism of death was hemorrhagic shock (60.5%).