Fifty children (5 to 15 years of age) with inactive compensated rheumatic heart disease were screened for traumatic hemolytic anemia. Eleven patients (22%) had normocytic hypochromic anemia. Their serum bilirubin and reticulocyte counts were significantly higher than those in the nonanemic group (P < 0.001); these levels suggest a hemolytic process. Direct Coombs' test was negative in all the patients studied. Haptoglobin level was significantly lower in the anemic group (P < 0.01). Only four cases (8%) showed hypohaptoglobinemia (serum haptoglobin less than 0.50 g/L), which denotes a mild intravascular hemolysis. The serum iron level was at the lower range of normal in these four patients, yet none of them had hemoglobinuria or hemosiderinuria.
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