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The high incidence of fungal keratitis in the studied population shows their vulnerability to such infections, which may result in devastating visual outcomes.

Métodos: Análise retrospectiva de 7 prontuários de pacientes com diagnóstico de melanoma de coróide, analisando: idade, sexo, cor, sintomas e duração, métodos de diagnóstico, tratamento realizado, tamanho e tipo do tumor e evolução. Resultados: Não existiu diferença em relação ao sexo e a idade média dos pacientes foi de 58,5 anos. O tumor predominou em brancos (66,5%) e baixa de acuidade visual foi o sintoma mais freqüente (66,5%). O diagnóstico deveu-se principalmente à oftalmoscopia indireta (66,5%) e todos realizaram ultrasonografia (USG). Todos pacientes foram submetidos a tratamento cirúr-gico, pois apresentavam tumores grandes (maior diâmetro basal superior a 12 mm à USG). O tipo mais freqüente foi o de celularidade mista (50%) e o tamanho médio dos tumores foi de 20,50 mm de maior diâmetro basal e 15,16 mm de espessura. O seguimento variou entre 8 meses e 5 anos. Dois pacientes apresentaram metástase à distância e evoluíram a óbito. Conclusões: Todos pacientes foram diagnosticados com o tumor em um estádio avançado, necessitando tratamento cirúrgico, com 2 pacientes desenvolvendo metástase à distância e evoluindo a óbito. Ressaltamos a importân-cia da oftalmoscopia indireta em função da malignidade do tumor e da possibilidade do diagnóstico precoce, ampliando as opções de tratamento e melhorando seus resultados.

Background The purpose of the current study is to report the anatomical and functional results of off-label human amniotic membrane graft as primary intervention to repair large to giant macular holes and in reoperations when wide internal limiting membrane peeling was unsuccessful. Methods Retrospective chart review was carried out in five different centers to identify all cases that had undergone off-label human amniotic membrane graft for the treatment of large or failed macular holes (MH). Data collected included age, gender, other concomitant diagnosis, symptoms duration, lens status, number of previous surgeries, macular hole measurements (minimum and base linear diameters), mean post-operative follow-up (months), and pre- and post-operative best corrected visual acuity (BCVA). Main outcome measures were anatomical MH closure rates and final BCVA (in logMAR). Nonparametric Wilcoxon rank-sum test was used because the data was not normally distributed, a P values < 0.05 were considered statistically significant. Results Nineteen eyes of 19 patients were identified and included in the study. Mean age was 66.21 ± 14.96 years and predominantly females (84%). All eyes had successfully closed MH with a single intervention with no recurrences during a mean of 9 ± 3.87 months follow-up. The median BCVA in logMAR preoperative was 1.30 ± 0.44 (0.80–2.0), approximately 20/400 on Snellen chart and the median BCVA in logMAR postoperative was 1.0 ± 0.72 (0.4–3.0) approximately 20/200 (p < 0.0001) with median of three lines of visual improvement. Conclusion The use of human amniotic membrane graft seems to be a viable and effective alternative for the treatment of large and persistent macular holes. However, further larger prospective controlled studies are necessary to confirm our preliminary results of this new surgical technique.

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