SUMMARYKnowledge of carriage and population dynamics of Staphylococcus aureus is crucial for infection risk assessment and to reveal transmission patterns of strains. We report the prevalence and molecular epidemiology of S. aureus in elderly people (n = 290) living in nursing homes in three cities in the south of Sweden. The overall carriage prevalence rate was 48% when results from nares (31%) and throat (34%) samples were combined. Common spa types were equally distributed but a frequent type, t160, was found only in one of the regions. Carriage of different spa types was detected in 23% of individuals and antimicrobial resistance rates were higher in S. aureus isolates from those carrying more than one spa type. Five of the 21 individuals who carried different spa types were colonized simultaneously with resistant and non-resistant strains. Seventeen per cent of the individuals carried S. aureus of the same spa type on all occasions. Methicillin resistance was not detected. In conclusion we found a high prevalence of S. aureus in this elderly population with a high rate of dual colonization with different spa types. We also found signs of institutional spread of one strain.

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Oral Abstracts 48AOS increased total bacteria count at day 14 (p=0.02, 95%CI 1.18-13.04), but not at day 30 (p=0.31,). Enteral supplementation of SC GOS/ LC FOS/AOS decreased faecal pH (p=0.01, 95%CI 0.54-0.93) and increased acetic acid (p=0.03, 95%CI 1.01-1.21). There was no effect on sIgA (p=0.50, 95%CI 0. 28-13.27). Antibiotics delay the intestinal colonisation (p< 0.001, 95%CI 0.08-0.22). Conclusions:Enteral supplementation with a prebiotic mixture consisting of neutral and acidic oligosaccharides increases the postnatal intestinal colonisation. However, administration of broad spectrum antibiotics decreased the growth of all intestinal microbiota. We suggest that caution should be given when considering initiation with broad spectrum antibiotics in preterm infants. 90EFFECT Background and aims: The increasing allergy prevalence may depend on a reduced microbial exposure early in life. Probiotics may prevent eczema in infants. Prenatal maternal supplementation might be crucial for this effect. The mixture of probiotic strains used in the present study reduced eczema when previously supplemented both pre-and postnatally. The aim of this study was to evaluate the effect of only postnatal probiotic supplementation on allergic manifestations during the first two years of life and to explore the impact of environmental factors on allergy development.

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The presence of resistance was generally low, and the greater part of the resistant cases was connected with 3 common antibiotics: ampicillin, trimethoprim/sulfamethoxazole, and ciprofloxacin. In spite of generally increasing resistance against third-generation cephalosporins in E. coli in Sweden, this study does not implicate residence at a Swedish nursing home as a risk factor for the acquisition of expressed cephalosporin resistance.