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Background: COPD is a great challenge as it is a main cause of morbidity and mortality around the world. COPD exacerbations increasing airway and systemic inflammation. Aim of this study: the study aimed to assess the role of MPV as a marker of inflammation in COPD patients and to evaluate its role as a prognosis parameter in AE COPD. Patients and Methods: This study was conducted at Zagazig University Hospitals, Chest Department, during the period from April 2017 till October 2017, the study included 25 stable and 25 exacerbated chronic obstructive pulmonary disease (COPD) patients, selected in non randomized manner. Results: showed that there was no significant statistical difference in RBCs, hemoglobin and hematocrit content and a highly statistical significant increase in white blood cells (WBCs) count, neutrophils count, while lymphocytes shows significant statistical increase among stable COPD group among studied groups. The results showed that the Validity of MPV cutoff value, Sensitivity was 76.0%, Specificity was 80.0%, +VE predictive was 79.1%, -VE predictive was 76.9% and the accuracy was 78.0%.Conclusion: MPV is an easily accessible low cost marker of inflammation in AECOPD. Decreased MPV values can be used as indicator for negative acute-phase reaction in the exacerbated COPD patients. Cut off-point of MPV<9.4 fl can be used as a threshold mean of bad outcome. Keywords; Mean Platelet volume, COPD exacebations, prognosis INTRODUCTION hronic Obstructive Pulmonary Disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually both progressive, associated with an abnormal inflammatory response of the lungs to noxious particles or gases and associated with systemic manifestations. [1] .COPD is a serious disease cause airflow obstruction. COPD also, associated with systemic inflammation such as blood leukocytes increase, inflammatory cytokines and C. reactive protein (CRP) [2] .The Mean platelet volume (MPV), blood count test which is important indicator the production rate of platelet and stimulation [3] .Many authors have reported that the increase in MPV can be considered as prognostic factor for pulmonary hypertension and thromboembolism in COPD patients. [4,5] However the association between Mean platelet Volume and Chronic Obstructive Pulmonary Disease is still controversial. Some authors reported that there were an C Mostafa I. et al….