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Aim:The purpose of this in vitro study was to evaluate the wear resistance and surface roughness of zirconia reinforced lithium silicate glass-ceramic (ZLS) compared to lithium disilicate glass-ceramic after simulated mastication.Materials and Methods: Thirty samples were prepared and divided according to the material of construction into three groups (n = 10). Group ( 1): E Max-CAD, Group (2): Celtra Duo ZLS, Group (3): Celtra Press ZLS. The sectioned samples of E-max CAD (Ivoclar, Vivadent, Schaan, Liechtenstein) blocks were polished and crystalized. The sectioned samples of Celtra Duo ZLS (Dentsply Sirona) blocks were glazed and fired. The Ingots of Celtra Press (Dentsply Sirona) were lab pressed, sectioned, glazed and power fired. The two-body wear testing was done using a chewing simulator integrated with thermo-cycling. Each ceramic sample was weighed and evaluated for surface roughness before and after the wear simulation test using an electronic analytical balance and optical profilometry, respectively.Results: IPS E-max CAD revealed the highest amount of weight loss with no statistically significant difference between groups as indicated by ANOVA test. The change in weight for each group was non-significant as demonstrated by paired t-test. The roughness mean value for E-max CAD was significantly decreased and recorded the lowest roughness change. Tukey's post-hoc showed a non-significant difference in the roughness mean value between Celtra Duo and Celtra Press. The roughness change for either Celtra Duo or Celtra Press groups was non-significantly increased as demonstrated by paired t-test.Conclusions: ZLS Celtra ceramics had insignificant less wear and significantly higher surface roughness with enamel antagonist compared to E-max CAD. Although wear and roughness were affected by the surface finishing of glass ceramics, the construction method of ZLS restorative materials had no significant impact on both.