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Aim: Cefpirome (CFP) in pure and pharmaceutical dosage forms determination by spectrophotometer; two very sensitive techniques have been developed. Materials and Methods: By mixing alkaline β-Naphthol (2-NPL) with diazotized cefpirome drug, we get the pink colour at λ max 544 nm in procedure I. Drug undergoes oxidation by ferric ion followed by complex formation with 2,2'bipyridine (2,2'BPD) to obtain a blood red colour at λ max 520 nm in procedure II. Under ideal conditions, the goal is to maximize the efficiency of procedure I and II. Results: Concentrations of 0.3-3.0 and 0.5-5.0 µg/ml are used in procedures I and II, respectively, where Beer's rule of molar absorptivity of 1.837 × 10 5 and 1.470 × 10 5 is followed. It is possible to calculate three different concentrations of RSD as well as RE (relative error). Conclusion: It was found that the novel procedures may be used to a wide variety of pharmaceutical formulations, and they are simple, consistent, economical, fast and highly reproducible.