Objective: The research works objective was to develop and test a gel that contained anthocyanin of Phaseolus vulgaris L. extract and to study it’s anti-inflammatory activity. Material and Method: By macerating Phaseolus vulgaris L. with 1% HCl (v/v) in methanol as the solvent, anthocyanin was extracted from the seed coat. Anthocyanin gels were produced utilizing a variety of polymers, including carbopol-940, sodium-CMC, chitosan, and other ingredients, including ethanol, lavender oil, propylene glycol, methyl paraben, and propyl paraben. All of the formulations of anthocyanin gel were studied for FTIR, pH, viscosity, spreadability, extrudability, drug content, and in-vitro drug release studies. The optimal formulation was then carried through a clinical investigation. Result and Discussion: Formulations for anthocyanin gels can be made utilising various gelling agents, such as carbopol-940, sodium-CMC, chitosan at different concentrations. Gel formulated using Chitosan (F3) showed better results of composition with decreased viscosity, enhanced extrudability, and a respectable amount of drug release. Formulation F3 by 2% of chitosan was best choice for anti-inflammatory activity in clinical study. Hence, Anthocyanin proved it’s potential for inflammation that implies moderate to marked improvement with significant results in subjects.