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Introduction: Diabetes is a very dangerous disease in the new age, and foot ulcer is one of its complications. If the foot ulcer is not quickly and properly treated, it may lead to amputation. Therefore, due to the importance of this issue, this systematic review was conducted with the aim of determining the treatment of diabetic foot ulcer with an epidemiological approach. Materials and Methods: The present study is a systematic review study that sought scientific articles in search engines, sites, and databases. This study, using the articles published over the past 24 years, has been associated with effective treatments for the accelerated healing of diabetic foot ulcers. In the first phase, 36 articles were found. of these, 12 articles related to the topic that was published in the last 24 years were reviewed. Results: In this study, several methods for the treatment of diabetic foot ulcers have been investigated. One of these methods that work in the treatment of foot ulcers is the "air cast diabetic walker boot" that inflates the airbag inside the boot to reduce stress on the skin. It has a hard outer cover and a deep heel that lowers the pressure. Conclusion: In the studies that have been studied, several therapeutic methods have been used to diabetic foot ulcers that have been effective. Considering that serious measures have been taken around the world to reduce complications of diabetes, including foot ulcers, but diabetes research centers in various countries and researchers working on diabetes must have serious plans to reduce complications of diabetic foot ulcers design and implement.

Objective: Menopause might lead to physical, mental problems for women and also disruption theirlife quality. Despite the existance of a single treatment to remove the disorders, herbal medicine is referable to chemical one in that they alleviate the related symptoms. The present research study aims to investigate the effect of Hypericum Perforatum L. on severity of early symptoms of menopause. Materials and Method: This double blind clinical trial study was conducted on 70 menopause women (two 35-person groups) picked out by a purposive sampling procedure. The first group received 160 mg Hypericum Perforatum L. (Perforin pill) while the second one received a placebo (ineffective pill). Menopause symptoms of 2, 4, 6, and 8 weeks after taking the pill or placebo were recorded in the 'Kupperman index' for menopause symptoms. The gathered data were then analyzed via independent t-test, one-way ANOVA, and repeated measure variance. Significance level was P≤0.05. Results: The age average in the medicine group was 50.49±2.74 and in the placebo group was 50.63±2.87. Body Mass Index (BMI) showed an overweight in both groups (27.29±0.75, 27.23±0.64). Furthermore, comparing the 'Kupperman index'for symptoms between the two groups in 6, 4, and 8 weeks after intervention revealed that the Hypericum Perforatum L. significantly had positive effects on alleviation of eraly menopause symptoms compared to placebo (P≤0.001). Conclusion: The results indicated that Hypericum Perforatum L. might alleviate the severity of early menopause symptoms. Thus, given its being economical and also its slight side effects, it is recommended as a suitable and desirable replacement for counterpart chemical medicine.