Background: The purpose of this research was to determine the prevalence of hypokalemia among patients undergoing acute [MI] therapy at the Department of Cardiology at HMC Peshawar. Methodology and Location of Study This was a research done at one location only: the Cardiology Division of H.M.C. Methods and materials: this research was carried out at the Cardiology Division at HMC Peshawar between January 1 and June 6, 2021). In all, 414 patients went through the trial's extensive screening (including history taking, routine questions, etc.). An electrocardiogram verified the suspected heart attack. Each patient had 5 mL of venous blood drawn and sent off to the lab to rule out hypokalemia. The same consultant pathologist with at least five years of expertise oversaw all laboratory testing. When the serum potassium level drops below 3.6 mmol/L, a diagnosis of hypokalemia may be made. The mean age of the participants was 63, with a standard deviation of 7.04 years; 240 (or 58%) were men and 174 (or 42%) were women.