Aims: Long term prognosis of hemodialysis patients are influenced by adequacy treatment. Thus, it is important to study the factors that improve the adequacy dialysis. The aim of this study was to determine the impact of isometric and isotonic movements during hemodialysis on dialysis adequacy. Materials & Methods: In this clinical trial in 2014, 50 patients in the two dialysis centers of Gonabad City and Qaen City, Iran, were selected by simple random sampling method and considering the inclusion criteria. The samples were randomly divided into two equal experimental and control groups. Experimental group patients performed isometric and isotonic movement according to tutorial film for 60 minutes in the first 2 hours of hemodialysis. These sport movement were repeated 3 times a week during hemodialysis session for 6 weeks. Dialysis adequacy was calculated before and after intervention in 2 groups. Data was analyzed by SPSS 14.5 software using independent T, Chi-square, Pearson-and Spearman correlation coefficients tests. Findings: After the intervention, there was a significant difference between two groups in adequacy of dialysis (p=0.01), in a way that before intervention, 80% of patients in experimental group had dialysis adequacy less than 1.2 which was reduced to 40% after intervention. However, the number of patients with less than 1.2 adequacy of dialysis in control group was increased from 72 to 76%. Conclusion: Performing isometric and isotonic movements during hemodialysis improves the adequacy of dialysis in hemodialysis patients.