Background Dental implants are one of the most prevalent operations in dental clinics, as they are the ideal solution to replace teeth. However, many patients who need this treatment are elder and suffering from heart diseases, especially atrial fibrillation, which requires anticoagulants. Non-vitamin k antagonist oral anticoagulants (NOACs) are considered modern anticoagulants, and they include four common medications; dabigatran, rivaroxaban, apixaban, and edoxaban. Material and Methods In this study, we review the literature regarding the proper management of patients receiving NOACs in dental implant clinics based on papers published in the last decade (2010-2022). A comprehensive search of the PubMed, Scopus, and Web of Science databases was conducted to identify articles that evaluated the relationship between Non-Vitamin K dependent oral anticoagulants and dental implant surgery. Results Despite the limitations of this study, it has been found that dental implants require discontinuation of NOACs for 24 hours or more prior to implant surgery. This depends on the type of anticoagulant and the creatinine clearance (CrCl). Conclusion Implant surgery requires interruption of NOACs ≥24 hours preoperatively. However, there is a need for further clinical studies in order to establish more evidence-based guidelines.

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