Air temperature (T, °C), relative humidity (RH, %), and global solar radiation (G, MJ.m-2 ) have been measured in the meteorological station at South Valley University (SVU) at Qena, Egypt, from 2000 to 2013, while the total column ozone (TCO, DU) is downloaded from Giovanni's website. T, RH, and TCO are important meteorological parameters, and they are useful to estimate the missing data of the global solar radiation (G), as global solar radiation is desirable for electricity generation applications and for agriculture. Qena is a subtropical region in Upper Egypt, as it's characterized by clear weather most days of the year, and it's very hot in the summer and cold in the winter. The meteorological station at South Valley University (SVU) stopped measuring the G. The linear regression equation and the most important statistical indices are used in this paper such as, the determination coefficient (R2 ), the mean absolute error (MAE), the mean absolute bias error (MABE), the mean square error (MSE), the root mean square error (RMSE), the mean percentage error (MPE), the mean bias error (MBE), the model efficiency (ME), and the agreement index (d). For verification of the empirical models' efficiency, the data of a new period has used, 2013, and the results of the models were excellent and valid for estimating the missing data, as R2 was more than 0.92 in all models but it was near one in models 1 and 4. MAE was close to zero for all models. MBE, MPE, and MABE were close to zero for all models except model 3. Model 1 was the best one, as, R2 , MAE, MABE, MSE, RMSE, MAPE, d, ME, and MPE were 0.9883, 0.0193, 0.383, 0.2303, 0.4799, 1.927, 0.9979, 0.992, and 0.2932, respectively