Fever of unknown origin (FUO) is caused by various diseases, and infections were the most frequent causes of FUO. The progress of the diagnostic techniques may have changed the breakdown of diseases causing FUO. This prospective study aimed to explore the clinical spectrum of fevers of undetermined origin (FUO) among adult patients treated at the Imbaba Fever Hospital from June 2018 to May 2019.All Egyptian patients who met the FUO criteria and were hospitalized during this period were followed up until they were diagnosed. They were 350 of whom186 females (53.1%) and 164 males (46.9%), with ages ranged from 18 to 82 years (32.77±14.4). The commonest FUO cause was infections (72%), followed by autoimmune diseases (20%), malignancies accounted (2%) of the total with the diagnosis unknown in 4.6%. Brucellosis and pneumonia were considered major causes of infections.
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