Background: Disorders related to intra-uterine fetal growth usually had different perinatal morbidity and mortality. Accurate diagnosis of intrauterine fetal growth is a challenging difficult task, but recent technological advances are associated with significant improvements with positive impact on antenatal care. Aim of the work: The aim of this study was to evaluate the accuracy of the umbilical and middle cerebral artery Doppler indices [e.g. resistance index] in prediction of fetal outcome in pregnancies with intra-uterine growth restriction (IUGR). Patients and Methods: Forty-five pregnant females had been included in a prospective study. All had a confirmed diagnosis of IUGR. Doppler ultrasound used to record fetal middle cerebral artery [MCA] and umbilical and Doppler indices every one week (from 32 weeks onwards). Post-delivery birth weight, Apgar score at 0 and 5 minutes had been measured and correlated with Doppler indices. Results: One-fifth of the mothers participating in the study (20%) had pre-term birth and 6.7% missed the follow-up. Umbilical artery resistance index (RI) at a cut off value of (0.79) had a diagnostic accuracy of 93%. MCA RI best cut off value was 0.63 with diagnostic accuracy of 73.9%. Also, for C/U ratio had diagnostic accuracy of 92.9%. Finally, there was significant, proportional correlation between MCA RA and C/U ratio from one side and APGAR score at 0 and 5 minutes from the other side. However, the correlation between UARI and Apgar score was inverse and statistically significant. Conclusion: Doppler velocimetry of fetal circulation can provide important information regarding fetal well-being, with subsequent impact on fetal outcome.

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Background The literature has always controversies on the use of freeze-all policy in high-responder women performing intracytoplasmic sperm injection. In this article, we discuss the benefits of freeze-all policy on the incidence of pregnancy outcomes and the complications. The main body of abstract Freeze-all policy is applied to the intracytoplasmic sperm injection program by freezing of all embryos and delaying embryo transfer to another subsequent ovarian cycle, to decrease the incidence of ovarian hyperstimulation syndrome, especially in high-responder women. Unfortunately, freeze-all policy is correlated with an increase in the economic costs and more ICSI laboratory effort. Delayed embryo transfer (ET) is correlated with more anxiety among the patients. An alternative strategy is to perform fresh embryo transfer with more intensive luteal phase support to compensate for the negative effect of the GnRH agonist on the endometrial receptivity and luteal phase support. Short conclusion The freeze-all policy had better pregnancy rates with less incidence of moderate to severe hyperstimulation syndrome compared with original fresh embryo transfer in high-responder women performing intracytoplasmic sperm injection.