During and after the green revolution in the last century, agrochemicals especially nitrogen (N) were extensively used. However, it resulted in a remarkable increase in crop yield but drastically reduced soil fertility; increased the production cost, food prices, and carbon footprints; and depleted the fossil reserves with huge penalties to the environment and ecological sustainability. The groundwater, rivers, and oceans are loaded with N excess which is an environmental catastrophe. Nitrogen emissions (e.g., ammonia, nitrogen oxide, nitrous oxide) play an important role in global climate change and contribute to particulate matter and acid rain causing respiratory problems, cancers, and damage to forests and buildings. Therefore, the nitrogen-polluted planet Earth needs concerted global efforts to avoid the disaster. Improved agricultural N management focuses on the synchronization of crop N demand and N supply along with improving the N-use efficiency of the crops. However, there is very little focus on the natural sources of N available for plants in the form of diazotrophic bacteria present inside or on the root surface and the rhizosphere. These diazotrophs are the mini-nitrogen factories that convert available (78%) atmospheric N2 to ammonia through a process known as “biological nitrogen fixation” which is then taken up by the plants for its metabolic functioning. Diazotrophs also stimulate root architecture by producing plant hormones and hence improve the plant’s overall ability to uptake nutrients and water. In recent years, nanotechnology has revolutionized the whole agri-industry by introducing nano-fertilizers and coated/slow-releasing fertilizers. With this in mind, we tried to explore the following questions: To what extent can the crop N requirements be met by diazotroph inoculation? Can N input to agriculture be managed in a way leading to environmental benefits and farmers saving money? Can nanotechnology help in technological advancement of diazotroph application? The review suggests that an integrated technology based on slow-releasing nano-fertilizer combined with diazotrophs should be adopted to decrease nitrogen inputs to the agricultural system. This integrated technology would minimize N pollution and N losses to much extent.

The public health sector and the global economy are facing the challenges of the epidemic of coronavirus disease 19 (COVID-19) since December 2019. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an emerging outbreak and spreading rapidly across the globe. The COVID-19 pandemic of unprecedented proportions has devastated almost all countries and pervaded globally. However, various vaccines have been developed to achieve immunity against the virus and limit transmissibility. By 18 November 2021, 52.6% of the world population got first dose of the COVID-19 vaccine. South Asia shares 15% fully vaccinated and 22.6% partially vaccinated population in the world. The 56.5% of South Asian Association Regional Cooperation (SAARC) regions, consisting of Pakistan, Afghanistan, Bangladesh, India, Sri Lanka, Nepal, Maldives, and Bhutan, got the first shot of COVID-19 vaccine, whereas 30.5% were fully vaccinated. India has the highest percentage of the vaccinated population of about 46.5% among SAARC countries. Although South Asian countries have unstable multiple socio-economic factors, including poverty, overpopulation, low literacy about medical care and medical systems, etc., the increasing trend in vaccination status has been observed. The high percentage of health budgets of SAARC countries was utilized for purchasing COVID-19 vaccines. This report observes that South Asian countries have been significantly tackling the threats of COVID-19.

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