Despite the fact that menstruation is a natural occurrence, it is associated with myths. Adolescent females are more likely to experience dysmenorrhea and menstrual misery. School dropouts are widespread among girls. Tiredness, backaches, and headaches are other common menstruation symptoms affecting school attendance. A better understanding of how menstruation affects absenteeism at school or college students' academic achievement can lead to changes in infrastructural facilities. Comprehensive community educational efforts that promote awareness and understanding among girls, their families, schools, and communities is a major element in keeping girls in school. There has been continuous inquiry to investigate the workplace experience of menstruation. This chapter looked at knowledge of menstruation, impact of menstrual distress on interpersonal relationship, school attendance, academic performance, and work productivity. This chapter highlighted the available coping strategies and proposed recommendations at individual, familial, societal, national, and international level.