The most serious problem in health care setting is over use and misuse antibiotics particularly in Iran. In 2017, some programs were implemented by the Iranian Ministry of Health (MOH) to controlling the antibacterial agent consumption in hospitals. This study evaluates the impact of implementation a restriction policy in Ghaem university hospital, which tries to limit the prescription of eight expensive antibiotics. Method: According to this policy the prescription of these antibiotics were only allowed by infectious disease specialists. The restriction policy of expensive antibiotics were initiated from April 21, 2018. We compared the consumption of these eight expensive antibiotics during 2 trimesters before and after the administration of this restriction policy. We also measured these drugs usage during the same period in previous year (April 21-July 22, 2017). Results: The consumption was decreased 37.7% during trimester after the starting of restriction plan compare to similar period before it (p = 0). The consumption had also declined compare to the same period in previous year. Conclusions: This simple restriction policy was effective in decreasing the antibiotic usage in Ghaem university hospital.