We previously reported that μ-oxo N,N’-bis(salicylidene)ethylenediamine iron [Fe(Salen)], a magnetic organic compound, has direct anti-tumor activity, and generates heat in an alternating magnetic field (AMF). We showed that Fe(Salen) nanoparticles are useful for combined hyperthermia-chemotherapy of tongue cancer. Here, we have examined the effect of Fe(Salen) on human glioblastoma (GB). Fe(Salen) showed in vitro anti-tumor activity towards several human GB cell lines. It inhibited cell proliferation, and its apoptosis-inducing activity was greater than that of clinically used drugs. Fe(Salen) also showed in vivo anti-tumor activity in the mouse brain. We evaluated the drug distribution and systemic side effects of intracerebrally injected Fe(Salen) nanoparticles in rats. Further, to examine whether hyperthermia, which was induced by exposing Fe(Salen) nanoparticles to AMF, enhanced the intrinsic anti-tumor effect of Fe(Salen), we used a mouse model grafted with U251 cells on the left leg. Fe(Salen), BCNU, or normal saline was injected into the tumor in the presence or absence of AMF exposure. The combination of Fe(Salen) injection and AMF exposure showed a greater anti-tumor effect than did either Fe(Salen) or BCNU alone. Our results indicate that hyperthermia and chemotherapy with single-drug nanoparticles could be done for GB treatment.

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: A microwave power beaming system was developed to realize wireless power supply to a Micro Aerial Vehicle. This system consists of transmitting, tracking, and receiving systems. In the transmitting system, a 5.8 GHz microwave beam was irradiated from an active phased array antenna. Transmitting power was 4 W and the beam divergence angle was 9 deg. In the tracking system, a 2.45 GHz pilot signal was detected by a two-dimensional tracking antenna and the position was deduced though the software retro-directive function. The maximum tracking error was 1.97 deg in the azimuth direction and 1.79 deg in the radial direction. In the receiving system, a light-weight flexible patch rectenna was developed using felt pad as substrate. The maximum rectenna efficiency of 45.3% was obtained with a 100 Ω road at 63 mW input power. By integrating these systems, auto-tracking wireless power supply was demonstrated to a MAV model circling at the altitude of 1,500 mm. As a result, a motor was kept rotated. Received power was 24.3 mW at maximum and 17.6 mW on average and the total transmission efficiency was estimated at 0.60%.

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