Ozone was discovered over a hundred years ago and since then, it has been widely used in many areas, with the primary use as a disinfectant in various ways, but with applications in diverse conditions. More recently, the use of ozone has extended to other fronts, using it to treat different pathologies. Extensive studies have shown its effects, as well as the safety of its application in various modalities of use. Other studies showed its toxicity, which depends on the doses of use. Emerging evidence revealed that ozone also plays an important role in the wound healing and modulation of immune cells, describing the molecular pathways responsible for these actions and describing therapeutic actions in the treatment of wounds, pain, postoperative and infectious diseases. Ozone use has already been documented in different doses, forms of use and routes of application, depending on the clinical situation and an adaptation is necessary for a better result. Thus, this review summarizes the main clinical uses of ozone, presenting the molecular pathways responsible for its actions, as well as discussing the main routes of use, doses and, vehicles used in the clinic.

The genus Cecropia belongs to the Urticaceae family and has a wide diversity of species in several regions of South America. In folk medicine, they have many uses, such as hypoglycemic, antihypertensive, anti-inflammatory, and sedative. Species of the genus Cecropia, such as Cecropia pachystachya, Cecropia glaziovii, and Cecropia obtusifolia, have been the subject of several phytochemical studies, and the main isolated compounds were orientin, isoorientin, isovitexin, vitexin, as well as c-glycosylflavonoid compounds. These active compounds were characterized as responsible for the use of Cecropia plants in the treatment of inflammation and also as antimicrobial agents. This review aims to describe the main characteristics of the genus Cecropia, exploring the compounds responsible for the medicinal uses of these species and focusing on anti-inflammatory and antimicrobial uses.

In this chapter, we will draw attention to the possibility of viral encephalitis caused by a common pathogen: dengue. To this end, it includes necessary knowledge of diagnosis and therapeutic management, such as general notions of infections in the central nervous system; viral encephalitis—diagnostic and therapeutic investigation; arboviruses and their relevance; dengue as an endemic disease; diagnostic methods and treatment; its possible clinical presentations and complications, among them, dengue encephalitis.

A hepatite C é uma patologia de etiologia viral que compete como uma das principais causas de hepatopatia crônica a nível mundial. Globalmente, estima-se que em torno 80 milhões de pessoas são portadoras do vírus C da hepatite (HCV). No Brasil, os dados apontam que 2.5% a 4.9% da população está infectada pelo vírus. Objetivo: realizar a caracterização clínica, o geoprocessamento dos casos e identificar o perfil genotípico dos pacientes portadores de hepatite C admitidos pela 20ª Regional de Saúde do município de Toledo-PR, Brasil. Metodologia: estudo epidemiológico, retrospectivo e descritivo, tendo como fonte de coleta de dados os prontuários médicos e exames da 20ª Regional de Saúde do município de Toledo-PR, referente ao período de janeiro de 2015 a agosto de 2020. Resultados: dentre os 137 casos analisados, observou-se predominância de indivíduos do sexo masculino (58%), com entre 56 e 65 anos de idade (31%), de etnia autodeclarada branca (58%) e com ensino fundamental incompleto (43%). A hipertensão arterial sistêmica foi a comorbidade mais frequente (18%). Houve predominância do genótipo 1 (46%). Sofosbuvir+Daclatasvir+Ribavirina correspondeu ao esquema terapêutico mais utilizado (11%). F1 foi o grau de fibrose hepática mais comum (16%). Quanto à densidade de casos, o município de Toledo liderou com 46 portadores. Conclusão: as características sociodemográficas, clínicas e genotípicas dos pacientes portadores de hepatite C variam de acordo com a região geográfica e, portanto, a realização de estudos epidemiológicos deve ser estimulada.