No abstract

A chiral phosphoric acid-catalyzed one-pot enantioselective reductive amination of 2-pyridyl ketones was realized to provide chiral pyridine-based ligands in excellent yields with high enantioselectivities (up to 98% yield, 94% ee). Computational studies on the key intermediate imine and transition state of the hydride transfer process revealed that the nitrogen atom of the pyridyl ring might be an important factor to significantly promote both the reaction activity and enantioselectivity.

Catalyzed by Gold Complex/Broensted Acid Binary System. -The asymmetric gold-catalyzed cyclization of substrates (I) provides spiroacetals (II) with high enantioselectivities and racemic spiroacetals (III) as by products. -(REXIT*, A. A.; MAILIKEZATI, M.; Tetrahedron Lett. 56 (2015) 21, 2651-2655, http://dx.