Career and college readiness interventions have been associated with numerous benefits for students. This chapter presents a case study of a developmental, comprehensive, culturally responsive career and college readiness unit. This chapter aims to demonstrate how one school counselor implemented a college and career readiness intervention through a culturally responsive lens, generating insights that potentially benefit comprehensive school counseling programming. Implications for K–12 school counselors to foster culturally responsive career and college readiness by using data to inform decisions, ensuring students at all grade levels are exposed to career awareness and exploration by using a tiered systems approach and developing a culturally affirming college culture, are discussed.