Background: BRAF p.V600E is reported in up to 80% of ameloblastomas. Despite the high frequency, the presence of this mutation in different histopathological areas of the tumour has not been investigated. This information has an important role in the use of BRAF p.V600E assessment as an auxiliary tool in the differential diagnosis between unicystic ameloblastoma and other odontogenic cystic lesions, especially when only incisional biopsies are available. Therefore, the purpose of the present study was to investigate BRAF p.V600E heterogeneity in unicystic ameloblastoma.Methods: Five cases of ameloblastoma and two dentigerous cysts were analysed.The regions exhibiting different microscopic characteristics were selected from each ameloblastoma case and manually dissected. TaqMan allele-specific qPCR or Sanger sequencing was performed to determine BRAF p.V600E status. Results:We screened the mutation in a small cohort of UA and no molecular heterogeneity was found. Four cases of ameloblastoma (80%) exhibited BRAF p.V600E in all different areas evaluated. One case did not harbour the mutation in any microscopic region analysed. The BRAF mutation was absent in the dentigerous cysts. Conclusion:Ameloblastomas appear to exhibit a homogeneous profile regarding the BRAF p.V600E no matter what histological feature is observed under light microscopy, suggesting that this molecular test may contribute to establish the correct diagnosis in cases microscopically resembling other odontogenic lesions.

Giant osteoma appears as a benign nonodontogenic tumor of craniofacial and jaw bones with potential growth. This type of tumor affects different maxillofacial regions, thus requiring proper planning to resolve the patient’s esthetic and/or functional complaints. Medial impairment of the mandible can compromise upper airway (UA) dimensions,  leading to respiratory disorders. However, to date, there is a lack of information in the literature about 3D UA imaging protocols for surgical planning. Accurate evaluation, elucidating the involvement of the upper airway patency, may demonstrate the need and urgency for surgical intervention. Therefore, our study aim  report a case of a giant mandibular osteoma, associated with a sudden constriction of the oropharyngeal space that was assessed by a Computer Software. The UA was assessed all dimensions, and determining the surgical procedure. In follow up could observed an improvement of UA and patient complain. This study emphasizes the importance of the detailed preoperative assessment of giant osteoma to determinate the correct approach.

Mandibular fractures are the most common in children, however with a low incidence because of child anatomy. Among the sites, the condyle is one the most fracture site, being a dilemma to surgeons about your management. The treatment to condyle fracture can be a surgical approach or conservative management. Conservative treatment presents the IMF, appliances, soft diet, and physiotherapy as an option, and these treatments can be applied isolated or associated. Physical Therapy has been a few reported in the literature as isolated therapy, reported as complementing the surgical approach, or after orthodontic/appliances therapy. Promote early mandibular mobility is important to restore function and prevent future complications such as ankylosis. Instruments to perform physiotherapy are expensive and not accessible to the entire population. Therefore, the present study presents a case of a pediatric patient with condyle fracture treated with a soft diet and physiotherapy with wooden spatula.

The aim of this study was to evaluate, through microscopic analysis, the repair of critical defects in rabbit calvaria after the use of particulate autogenous bone or particulate autogenous bone associated with inorganic biomaterial. Six male albino rabbits, New Zealand, were used, in which 4 defects were performed in each calvaria and randomly divided into 4 equitable groups: Group I – performed bone defect; Group II – performed bone defect and filled with particulate autogenous bone; Group III – performed bone defect and filled with particulate inorganic material (Bio-Oss®, Geistlich from Brazil); Group IV – performed bone defect and filled with particulate autogenous bone associated with particulate inorganic material (Bio-Oss® - Geistlich from Brazil) with proportion being 20:80. The analyze time of the procedure was 60 days. The microscopic analyze allowed to conclude that the autogenous, the Bio-Oss® and the Bio-Oss® associated with autogenous bone groups showed a bone neoformation on the defects, characterizing the material osteoconductive. However, the complete defect closure occurred on the autogenous bone and the autogenous bone associated with the inorganic bone, showing that the presence of the autogenous bone improves the characteristics of the biomaterial. The use of inorganic bone associated with the autogenous bone allowed a complete bone neoformation of the critic defect in the calvaria of rabbits.

Surgical management of impacted third molars is a treatment performed by dentists and its indicated for various conditions, among the indications has the prevention of mandibular fracture, but this is a factor that has been discussed and is controversial. Fractures caused by a third molar can occur, and on the other hand, the fractures after or during the management of impacted third molar are a possible complication. Surgical planning as the indication to the surgery has to be performed to avoid complications as the fracture. Thus this study aims to report a case about a mandible fracture after third molar extraction, presenting edema, pain, and restriction in mandible mobility in 01-day follow-up. A 27-year-old female was referred to the oral and maxillofacial surgery service of the Santa Casa Hospital of Araçatuba (Araçatuba, Brazil), reporting dental history of third molar removal, with immediately chief complaints. In the assessment, the patient presented edema, pain, malocclusion, and restriction in mandible mobility, and the panoramic X-ray showed a mandible fracture with displacement. The patient underwent surgery under general anesthesia to open reduction with internal fixation (ORIF) through an intraoral approach. On the follow-up, the patient showed an improvement in mouth opening and mandibular mobility without pain or infection signs. The panoramic X-Rays showed us the bone fracture healing.