Actigraphic measurement of motor activity during the evaluation of IADLs and motor tasks is a potential objective tool in detecting early changes in MCI. Depressive symptoms seem not to be associated with motor activity in MCI subjects.

Background: The olfactory identificationdysfunction in amnestic mild cognitive impairment (aMCI) which precedes mainly Alzheimer disease (AD) is well known and is considered to be caused by AD pathology. The presence of olfactory impairment in non amnestic MCI (naMCI) and patients with subjective memory complaint (SMC) is controversial. The aim of this study was to examine the degree of objective and subjective olfactory dysfunction in aMCI, naMCI and SMC. Methods: 92 patients with aMCI and 32 patients with naMCI, 28 SMC patients and 50 age matched healthy controls underwent a multiple choice olfactory identification test with 18 different odors developed in our memory clinic. Results: Both aMCI and naMCI patients showed impairment in olfactory identification test compared to both controls and SMC (p<0.01). There was no difference between aMCI and naMCI groups and between SMC and controls in olfactory identification. Conclusions: The olfactory identification impairment in naMCIand aMCI isindistinguishable. NaMCI often converts to Frontotemporal lobar degeneration, dementia with Lewy body or Vascular dementia and the olfactory deficit found in this study could be explained by the recently demonstrated olfactory impairment in these dementia subtypes. SMC patients do not have any significant olfactory discrimination impairment. P3-173 HOW SHOULD WE ASSESS FUNCTIONAL PERFORMANCE IN INDIVIDUALS WITH MILD COGNITIVE IMPAIRMENT (MCI)?Patricia Background: A number of studies have recently examined functional performance of individuals with MCI and found that these individuals face functional declines. Despite the relevant findings, the literature in this area has a number of limitations: 1) functional performance has been assessed using different types of measures (e.g., self report, informant report, questionnaire, performance-based activities), producing different estimates of functional abilities; 2) there is little consistency between studies on MCI criteria; 3) many studies do not indicate the MCI subtype, even though type directly impacts on functional performance, and 4) few studies have evaluated the performance-based (e.g., organization, initiation, planning, remembering, etc...) components affected. Thus, to date there is no consensus on how to assess functional performance in this population and clinicians are still left without much guidance in this area. The goal of our study is to develop an evidence-based guideline for the screening and assessment of functional performance in individuals with MCI. This presentation will focus on the analytical framework used for the development of the guideline and preliminary findings. Methods: The methodological approach used was adapted from the U.S. Preventive Service Task Force (USPSTF). The goal of the USPSTF is to take a more evidence-based approach to the development of clinical practice guidelines. It uses an analytic framework to guide the literature search for admissible evidence, including literature findings that are classified as overall good, fair or poor. T...