Objectives: To determine the frequency of Temporary epicardial pacing wires usage and its predictors in theimmediate postoperative period in isolated coronary artery bypass graft surgery.Method: The longitudinal study was conducted at the Aga Khan University Hospital, Karachi, from September2019 to August 2020, and comprised adult patients of either gender who underwent isolated coronary arterybypass graft in the Department of Cardiothoracic Surgery. Demographic, peri-operative and post-operativeTemporary Epicardial Pacing Wires use data was extracted from patient's files and the institutional electronicdatabase. Logistic regression models were built to explore predictors of Temporary epicardial pacing wires usage.Data was analysed using SPSS 22.Results: Of the 322 cases evaluated, 27(8.4%) required the use of Temporary Epicardial Pacing Wires. Mean age ofthe patients requiring temporary epicardial pacing wires was 66.3±8.9 years compared to 58.7±8.9 years in thosewho did not require it (p<0.001), while the left ventricular ejection fraction percentage was 44.1±12.8 and 48.9±12.8respectively (p=0.032). After adjusting for clinically plausible demographics and peri-operative variables, increasingage and low left ventricular ejection fraction were significantly associated with the use of temporary epicardialpacing wires in post-operative period of isolated coronary artery bypass graft patients (p<0.05).Conclusions: The frequency of temporary epicardial pacing wires usage in the post-operative period of coronaryartery bypass graft was found to be low.Keywords: Arrhythmias, Adult cardiac surgery, Electrodes, Post-operative, Temporary Epicardial pacing.