Introduction:Many genetic studies are conducted on Obsessive-Compulsive Disorder (OCD). however, a high-throughput examination of proteome profile of this severe disease has not been performed yet.Methods:Here, the proteomic study of OCD patients’ serum samples was conducted by the application of Two-Dimensional Electrophoresis (2DE) followed by Mass Spectrometry (MALDI-TOF-TOF).Results:A total of 240 protein spots were detected and among them, five significant differentially expressed protein spots with the fold change of ≥1.5 were considered for further evaluations. These proteins include IGKC, GC, HPX, and two isoforms of HP. While IGKC and HP show down-regulation, GC and HPX indicate up-regulation. Moreover, a validation study of overall HP levels in patients’ serum via nephelometric quantification confirmed the lower levels of this protein in the serum of OCD patients. Additionally, enrichment analysis and validation test revealed that inflammation is one of most dominant processes in OCD.Conclusion:It is suggested that these candidate proteins and their underlying processes (especially, inflammation) may be linked to OCD pathophysiology and can promise a clinical use after extensive validation studies.

BACKGROUND: The main concept of risk management in the emergency department (ED) contains a broader meaning, so that; it's known as a sudden event or situation which would happen at an uncertain future that has some negative or positive impacts which could be called threat or opportunity respectively. However, the knowledge of risk management could cover the overall procedures involved with administering the planning of risk management, identification, investigation, monitoring and also step by step clinical examination. One of the main tools for preventing adversities is evaluating and management of possible risks. AIM: One of the main objectives of the present study is recognising the most frequent types of the risk happening in the EDs. Moreover, the present study is trying to evaluate the possible risks which could happen among various ED sections. METHODS: Six databases of EMBASE, HubMed, Cochrane Library, MEDLINE, PubMed, CHBD and Goggle scholar were chosen for discovering much-related articles from the year 2005 to 2019. A total number of 68 were chosen finally to be reviewed more precisely based on the main objective of the present study. RESULTS: Precise planning, preparing sufficiently and conducting the process of continuous monitoring are needed for ensuring the fact that any possible risks could be managed through these planned strategies. On the other hand, by modifying the patients' beliefs, anticipations and the available social culture about the importance of risk management issue, the overall objective of the present study could be achieved at higher rates. CONCLUSION: Moreover, because the potential of occurrence of risk in EDs is high and approximately more than half of them are fatal, more precise adequate systematic plans for management of them should result.

Background: Coronavirus disease 2019 (COVID-19) is associated with diffuse alveolar damage (DAD) and coagulopathy in severe ill patients. Objective: To better understand and disease management, we investigated postmortem needle biopsies of lung, liver, and kidney pathologic changes along with clinical course, hematologic and imaging findings in two COVID-19 decedents. Patients and method We examined pathology of two patients with confirmed positive SARS-CoV-2 test died from respiratory failure. Computed tomography (CT) of the chest, Clinical and laboratory findings were investigated. Postmortem needle biopsies of lung, liver, and kidney were performed with complete protection. Results: The patients died from acute respiratory distress syndrome (ARDS). One of the patients was 56-year old man without any predisposing factor and the other (83-year old man) had hypertension, diabetes mellitus and renal failure. The patients had lymphopenia, elevated C-Reactive Protein (CRP), ferritin and D-Dimer. Axial CT images show diffuse ground glass opacity with some crazy paving and consolidation. The main pathologic finding of lungs revealed DAD. Intravascular micro-thrombi were detected despite anticoagulant prophylaxis. Renal autopsy demonstrated acute tubulointerstitial nephritis (ATIN) with tubular epithelium attenuation. Liver biopsy was consisted of lobular and portal inflammation and steatosis Conclusion This study emphasis that diffuse alveolar damage and microvascular pulmonary thrombosis in SARS-CoV-2 patients caused by either direct viral cytopathic effect or host immune and inflammatory reaction. Due to severe hypoxemia in COVID-19 patients suffering ARDS, appropriate oxygen support and anticoagulation therapy with strict monitoring is recommended Histopathologic findings in COVID-19 Autopsies from IRAN: A comprehensive report of laboratory, chest Computed tomography (CT) and morphology findings

Introduction: Down syndrome as a genetic disorder is a popular research topic in molecular studies. One way to study Down syndrome is via bioinformatics. Methods: In this study, a gene expression profile from a microarray study was selected for more investigation. Results: The study of Down syndrome patients shows specific genes with differential expression and network centrality properties. These genes are introduced as RHOA, FGF2, FYN, and CD44, and their level of expression is high in these patients. Conclusion: This study suggests that besides chromosomes 21, there are additional contributing chromosomes to the risk of Down syndrome development. Besides, these genes could be used for clinical studies after more analysis.

Introduction: Widespread application of lasers in different fields of medicine implies more investigations into the molecular mechanism of laser effects on the human body. Network analysis of the dysregulated genes of Saccharomyces cerevisiae samples are irradiated by a UV laser and harvested 30 minutes after radiation compared with a 15-minute group is the aim of this research. Methods: The significant dysregulated genes interacted via the STRING database, and the central nodes were determined by "Networkanalyzer" application of Cytoscape software. The critical genes and the related biological terms were identified via action map analysis and gene ontology assessment. Results: The gene expression profiles of the samples with 30-minute post-radiation time were different from the samples with 15 minutes of post-radiation time. 9 potent central genes, 50% of which were similar to the nodes of the 15-minute group, were identified. The terms "positive regulation of telomere maintenance" were targeted in the two sample groups. Conclusion: In spite of large alteration in the gene expression profiles of the samples, the results indicated that the main affected biological term for the 15-minute and 30-minute groups was similar.