Introduction: Recently, the health care sector has been moved towards establishing non-governmental organizations (NGOs); due to the fact that collaborative approaches are happening more in these organizations and they provide better services.This collaboration has been conducted in a variety of ways, requiring the investigation of a study with the aim of providing a management pattern of health benefactors’ collaboration in medical sciences Universities of Iran. Methods: This is a qualitative and Delphi study conducted in 2017. The study population was 13 universities out of 57 universities of medical sciences in Iran to which the questionnaire was sent. To obtain experts’ opinion and consensus, using Delphi technique, a questionnaire with initial classifications and subclasses was electronically sent to the social deputy of the universities of medical sciences for three times. In order to ensure the consistency of the experts, their responses were analyzed by Kendall correlation analysis in 5 phases. SPSS and Excel software were used to analyze the data. Results: The findings of this study showed that the factors affecting the participation of the benefactors in the medical sciences Universities of Iran include: holding meetings in the beginning of the academic year of the universities, holding meetings in special timeframes, and using benefactors’ financial resources in the research field. the Kendall coefficient was 61% in the first stage. By improving the questionnaire in the second stage, the Kendall coefficient reached 86%, and in the third stage of validation, it increased to 91%. Conclusion: The management pattern of collaboration can be used to improve the management of health benefactors’ collaboration in Iran Universities of Medical Sciences, and the highest priority to improve its performance depends on the organization and guidance among its members.