Background: The study aimed to assess if manual therapy, compared to ibuprofen, impacts the concentration of inflammatory factors, sex hormones, and dysmenorrhea in young women Methods: Thirty-five women, clinically diagnosed with dysmenorrhea, were included in the study. They were divided into group A—manual therapy (n = 20) and group B—ibuprofen therapy (n = 15). Inflammatory factors such as vascular endothelial growth factor (VEGF), C-reactive protein (CRP), prostaglandin F2α (PGF2α), E2 (PGE2) and sex hormones levels were measured. Dysmenorrhea assessed with the numerical pain rating scale (NPRS), myofascial trigger points, and muscle flexibility were examined before and after the interventions. Results: The difference in the level of 17-β-estradiol after manual and ibuprofen therapy was significant, as compared to baseline (p = 0.036). Progesterone levels decreased in group A (p = 0.002) and B (p = 0.028). The level of CRP was negatively correlated with sex hormones. Decrease in dysmenorrhea was significant in both groups (group A p = 0.016, group B p = 0.028). Non-significant differences were reported in prostaglandins, VEGF and CRP levels, in both groups. Conclusions: There were no significant differences in CRP, prostaglandins and VEGF factors after manual or ibuprofen therapy. It has been shown that both manual therapy and ibuprofen can decrease progesterone levels. Manual therapy had a similar effect on the severity of dysmenorrhea as ibuprofen, but after manual therapy, unlike after ibuprofen, less muscles with dysfunction were detected in patients with primary dysmenorrhea.

In August 2019 and during August/September 2020, the main collection system of the Wastewater Treatment Plant (WWTP) in Warsaw, Poland, malfunctioned. During that system failure, over 4.8 million m3 of untreated wastewater was dropped directly into the Vistula River in just a few days. It is currently considered as one of the largest known failures of WWTP worldwide. In order to assess the environmental impact, water samples were collected from 2 spots at the Vistula river estuary (406 and 415 km from the discharge location, respectively), and 4 spots at the Gulf of Gdansk, situated on the southern shore of the Baltic Sea. The sampling was conducted before the wastewater wave reached the Vistula river’s mouth, followed by daily sampling during 21 days after the malfunction occurred. The study showed the decline in water quality at the Vistula river estuary and the Baltic shore waters as the wave of wastewater reached those points, despite being situated over 400 km downstream from the place of the accident. Those changes included the reduction in the dissolved oxygen content (by 0.69-fold at its peak), the increase in Total Organic Carbon (TOC) (by 1.28-fold at its peak), nitrate-nitrogen (N-NO3) (by 1.68-fold at its peak), phosphorous (P) (by 2.41-fold at its peak), conductivity (by 16.8-fold at its peak), and Chemical Oxygen Demand (COD) (by 1.84-fold). In the samples from the Vistula river, the decline in water quality was seen as incidental and lasted 2–3 days. Subsequently, the levels of physical and chemical parameters returned to the levels from before the accident. However, the changes in the Gulf of Gdańsk lasted significantly longer, especially on the West side of the Vistula river, where, even after 21 days from the initial accident, some parameters remained altered.