BackgroundIn recent times, digital technologies in healthcare have been well recognized in Nepal. It is crucial to understand what is working well and areas that need improvements in the digital health ecosystem. This narrative review was carried out to provide an overview of Nepal's challenges and opportunities for implementing digital health interventions.MethodsThis study was conducted following PRISMA guidelines and used key search terms such as telehealth, telemedicine, e-health, mobile health, digital health, and Nepal to identify primary studies published between 1 January 2010 and 30 December 2021 in four databases, namely PubMed, Google Scholar, Scopus, and CINAHL. Initially, identified studies were screened against predetermined selection criteria, and data were extracted, and the findings were narratively synthesized.ResultThe review identified various challenges, opportunities, and benefits of implementing digital health initiatives in Nepal. The most expressed challenge was inadequate technical facilities (lack of electricity and internet) and rugged geographical distribution, making transportation difficult in hilly and mountain areas. Lack of skilled workforce and lack of supportive policies were also notable challenges documented. Meanwhile, major opportunities identified were education and training of the students and health practitioners and increasing awareness among the general population.ConclusionThe study identified various factors associated with the successful implementation of digital health initiatives in Nepal. Our findings may guide to formulation of digital health policy and interventions to improve mass health outcomes using digital health services.