Introduction: A great number of hereditary diseases have been correctly diagnosed and treated recently as a result of the rapid progress and constant development of genetic research. Case report: This study presents the case of 24-year-old female patient suffering from MELAS syndrome, which is inherited in the maternal line -as are other mitochondrial diseases. This disorder was first described in 1984 by Steven G. Pavlakis et al. Our paper describes prosthetic procedures that were undertaken as treatment for the patient mentioned above, who had been referred from a hospital neurological clinic for consultation and possible treatment due to her refractory migraines. Regardless of the previously noted symptoms, the patient was examined for bruxism, and considering the positive outcome of the test, typical treatment, including a stabilization appliance was implemented. It gives significant improvement and lesser occurrence of neurological symptoms. Conclusions:The patient stays under the constant, periodic control of our department. Keywords: MELAS syndrome; occlusal splint; bruxism; doxepin; venlafaxine; surface electromyography.