Aim:The aim of this prospective cohort study was to evaluate the postinsertion posterior single-implant occlusion changes at 3-and 6-month intervals using T-Scan computerized occlusal analysis. Materials and methods:A total of 21 patients received single implant, opposed by natural dentition, in posterior regions of the maxilla or mandible (13 premolar, 8 molar) and were finally restored with cemented-retained metal-ceramic crowns. The occlusal contacts were equilibrated according to the implantprotective occlusion concept to develop light contact with heavy occlusion and no contact with light occlusion in maximum intercuspation. The percentage of force applied to the implant crowns (POFI) and contralateral teeth (POFT) was evaluated using T-Scan computerized occlusal analysis at prosthesis insertion, 3-and 6-month follow-up appointments. The data were statistically analyzed using Friedman test and Wilcoxon post hoc test (α = 0.05). Results:The POFI values at the 6-and 3-month follow-up appointments were significantly higher than those at prostheses insertion (p = 0.001 and p = 0.005 respectively). In addition, there were significant differences between the POFI at 3-and 6-month follow-up (p = 0.020). However, the POFT values at 3-and 6-month follow-up appointments were significantly lower than those at baseline (p < 0.001). Conclusion:The intensity of occlusal contacts of implantsupported prostheses opposed by natural dentition gradually Clinical significance: A periodic occlusal adjustment of implant-supported prostheses is necessary to prevent potential overloading from the movement of opposing natural dentition. Post-insertion Posterior Single-implant Occlusion Changes at Different Intervals: A T-Scan