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In this work, new hydrogel films based on polyvinyl alcohol (PVA) and β-cyclodextrin (β-CD) were prepared with the aim of studying their ability as an antibacterial and drug carrier system. Gallic acid (GA) was used as an antibacterial drug which was encapsulated into the β-CD cavity, and finally, β-CD inclusion complex (GA/βCD-IC) was prepared. On the other hand, silver nanoparticles (AgNPs) were synthesized on the graphene oxide (GO) surface (GO-Ag), and the obtained GO-Ag was used to enhance the antibacterial properties and mechanical strength of their films. FT-IR and DSC analysis approved the formation of cross-linking with glutaraldehyde between the PVA and β-CD. Hydrogel films were characterized using XRD and SEM. The disc diffusion method showed the antibacterial activity for the films containing GO-Ag and GA. Due to the good strength, elasticity, WVP, and swelling ability, PVA/GA/βCD-IC/GO-Ag can be proposed as a potential antibacterial drug delivery system.